Taking Claudin 18

biokit
biokit 6/6/2016 8:03:53 AM
Taking Claudin 18.2 protein as a target of gastric cancer

Claudin18.2 (CLDN18.2) is a kind of tight junction proteins that express in a variety of cancers (including gastric and gastroesophageal junction adenocarcinoma). IMAB362 is a chimeric monoclonal antibody which can activate the killing of mediated ion specific CLDN 18.2- positive cancer cell by immune effector mechanisms. Now IMAB362 has proven its single-agent activity and for the pre-treatment of gastric cancer patients, it is safe and tolerable. There are also other recombinant proteins that can be developed with advanced technology.

A phase II study from Europe shows that for patients in advanced gastric cancer, the median survival time can be significantly prolonged when adding this new and pioneered IMAB362 antibody to standard chemotherapy (13.2 months vs 8.4 months). This treatment targets a protein called claudin 18.2. In this study, patients with the highest levels of claudin 18.2 protein showed longer median overall survival (16.7 months).

"Because claudin 18.2 protein abounded in the stomach tumor, we assess that half of advanced gastric cancer patients can be the candidates for this new therapy," the lead author of this study Professor Salah-Eddin Al-Batran (oncologists, Germany Mainz Frankfurt Nordwest hospital, and director of the clinical cancer Research Institute) said. "In addition, this unique target is not present in any other healthy tissues of the stomach wall, thereby minimizing side effects of treatment."
Claudin 18.2 protein is a novel cancer targets. In addition to gastric cancer, claudin 18.2 protein is also found in a variety of other cancers including pancreatic cancer, lung cancer, esophageal cancer and ovarian cancer. Claudin 18.2 protein belongs to tight junction family and can control the molecular flow of layer cells. However, in tumors, tight connection is broken, and then claudin protein lost its primary role.

IMAB362 is the first antibody that targets to claudin 18.2 protein. When this antibody attaches to claudin18.2 of the cancer cells, various types of cells and soluble immune effector which are coated on the antibody make a response by killing cancer cells. For more information about recombinant human proteins, Cusabio is a good choice.
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