CRISPR and Cas Genes Market Anticipated to Surge with an
Impressive CAGR of 20.1%

Transparency Market Research (TMR) has published a new report
titled, “CRISPR and Cas Genes Market
- Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2018–2026”. According to the report, the global CRISPR and
Cas genes market was valued at US$ 7,234.5 Mn by 2026,
expanding at a CAGR of around 20.1% from 2018 to 2026. Increase in applications
of CRISPR and Cas gene editing technology in bacteria and usage of gene editing
technology for prevention of various diseases are the major factors anticipated
to drive the market from 2018 to 2026. Rise in need of alternative medicine for
chronic diseases and increase in investments by key players in Asia Pacific are
projected to propel the market during the forecast period.

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Increase
in Usage of DNA-free Cas

DNA-free
Cas9 is most commonly used with synthetic crRNA tracrRNA and chosen by
researchers who strive to avoid unwanted vector DNA integration into their
genomic DNA. CRISPR-Cas9 utilizing mRNA or protein is ideal for applications
such as knocking of a fluorescent reporter using HDR or knockout cell line
generation. Advantages such as gene editing with DNA-free CRISPR-Cas9
components to reduce potential off-targets and potential usage of CRISPR-Cas9
gene editing to find correlations with human diseases in model systems drive
the segment.

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Rise in Incidence of Genetic
Disorders and Increase in Applications of CRISPR and Cas Genes to Propel
Market

Genetic
diseases are generally termed as rare diseases. According to NCBI, prevalence
of these rare diseases is approximately 5 in 10,000. There are 6,000 to 8,000
rare diseases, with 250 to 280 new diseases diagnosed every year. Hence, 6% to
8% of the global population is projected to be affected by rare diseases i.e.,
genetic diseases in the near future. Researchers are developing treatments for
these diseases with applications of new technologies such as CRISPR. The applications
of CRISPR technology are expanding in other industrial sectors. This is
expected to drive the market during the forecast period. Usage of CRISPR/Cas9
technology in plant research has enabled the investigation of plant biology in
detail which has helped to create innovative applications in crop breeding.
Site-directed mutagenesis and site-specific integration of a gene, which is
also called knock-in, are important in precision crop breeding.
Cas9/gRNA-mediated site-directed mutagenesis and knock-in is widely used in
rice and Arabidopsis protoplasts. CRISPR/Cas9 provides a simple method to
generate a DSB at a target site to trigger HDR repair.

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Ethical Issues Concerning Gene
Editing Technology to Restrain Market

Any changes
in the human genome are made in the germline, and hence are expected to be
passed on to the future generations. The safety and efficacy concerns with
genome editing have gained momentum with the discovery of CRISPR, as it has the
potential to make accurate use of genome editing technologies. Major ethical
issues concerning the human genome editing technology are disturbance of the
ecological equilibrium, patent regulations concerning CRISPR/Cas9 gene
technology, non-therapeutic interventions using human genome, and formation of
chimera which has the risk of violation of the order of nature and giving rise
to moral confusion for treating organisms.

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Asia Pacific Market to Witness
Exponential Growth

In terms of
revenue, the CRISPR and Cas genes market in Asia Pacific is expected to expand
at a CAGR of 22.0% during the forecast period. Growth of the market in the
region can be attributed to increase in incidence of chronic diseases such as
cancer and the need of development of genetic engineered treatment options.
According to the report, Call for Action: Expanding Cancer Care for Women in
India, 2017, an estimated 0.7 million women in India are suffering from cancer.
China dominated the CRISPR and Cas genes market in Asia Pacific. In 2016,
scientists based in China launched the first known human trials of CRISPR, the
genomic tech that involves slicing and dicing the body’s very source code to
fight cancer. Japan was the second largest market for CRISPR and Cas genes in
Asia Pacific.

Addgene, Thermo Fisher Scientific,
Inc., and Integrated DNA Technologies, Inc. to Lead Market

The report
also provides profiles of leading players operating in the global CRISPR and
Cas market such as Synthego, Thermo Fisher Scientific, Inc., GenScript,
Addgene, Merck KGaA (Sigma-Aldrich), Integrated DNA Technologies, Inc.,
Transposagen Biopharmaceuticals, Inc., OriGene Technologies, Inc., New England
Biolabs, Dharmacon, Cellecta, Inc., Agilent Technologies, and Applied StemCell,
Inc.

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