Download The Findit App

Share Your Posts On These Major Social Networks

Instatag Your Posts to Instagram Facebook + Twitter

News

Cannabidiol as a Therapeutic Agent for Skin Health

Cave Creek 5/14/2016 3:00:00 PM

The centrality of skin function to human health has meant that evolution endowed skin with complex biochemical networks of receptors and small molecules that continually survey and respond to inputs, and modify the reactions of resident cells to react to incoming information.

 One such network is the skin endocannabinoid system (SkECS), where endogenous and exogenous cannabinoids can act at numerous receptor sites to promote skin health. Cannabinoid receptors (CB1, CB2, TRPV1, TRPA1 and TRPV4) are present on multiple cell types in the human skin (fibroblasts, keratinocytes, immune cells, neurons, subcutaneous fat cells and muscle layers).

 The presence of the SkECS is a clear indicator that cannabinoids may be central to skin health. It also presents the intriguing possibility that exogenously applied cannabinoids could augment, initiate or supplement the roles that endocannabinoids play in the skin to therapeutic benefit.

Cannabinoids and their diverse receptors have been implicated in the proliferation of skins cells, in the differentiation processes that give rise to the multicellular complexity of skin, in hormone and mediator secretion that maintain skin tone, and in the activity of hair follicle cells and the sebaceous glands.

 

The SkECS maintains skin homeostasis, and loss of this homeostasis leads to disorders such as acne, dermatitis, itch, pain, psoriasis, sclerosis and excessive or unwanted hair growth.

 

CBD TARGETS FOR SKIN HEALTH

 

Epidermis – psoriasis – Phyto-cannabinoids inhibit keratinocyte proliferation, decrease keratinization and suppress cornified envelop formation; promote epidermal differentiation; inhibit proliferation of transformed (tumorigenic) keratinocytes.

Sebaceous glands – CB2 ligands stimulate lipid and sebum production and apoptosis of glandular cells.

Hair follicles – Anandamide inhibits hair shaft elongation and proliferation, promote intraepithelial apoptosis and catagen regression.

Dermatitis – Cannabinoid receptors suppress inflammation.

Dermal fibrosis – Cannabinoid receptors suppress fibrosis.

UV-B induced skin tumors and skin inflammation – Cannabinoid receptors suppress UV-B induced skin tumors and skin inflammation, resulting in decreased growth, angiogenesis, metastasis and apoptosis.

 

Sources and acknowledgments

“Evolved To Defend: Cannabinoid Protection Of Barrier Tissues In Plants And Humans”. Andrea L. Small-Howard, Ph.D.

More News

https://s3.amazonaws.com/findit-pictures/6469/51b8aa4a-011e-40c0-8f99-696b3155ebdf.jpg

CBD Unlimited Launches RubyBees Hemp Honey E-Commerce Sales


Released On: 7/8/2020
Views: 8444

https://s3.amazonaws.com/findit-pictures/6469/7e192d4d-3839-4212-b1de-649d6b3b4a87.jpg

Endexx Launches New Product line, Phyto-Drops CBD for Pets


Released On: 7/2/2020
Views: 8517

https://s3.amazonaws.com/findit-pictures/6469/23777589-3b64-4c01-8375-912c62ed536c.jpg

CBD Unlimited Proud Sponsor for the 2020 Arizona Man of the Year by the Leukemia & Lymphoma Society


Released On: 7/1/2020
Views: 8317

https://s3.amazonaws.com/findit-pictures/6469/2419df2a-498e-4089-83d1-b818fc935e94.jpg

Endexx Launches Investor Outreach and Ambassador Program


Released On: 6/30/2020
Views: 8997

https://s3.amazonaws.com/findit-pictures/6469/1ef70536-6141-4589-8da9-7501311cdfc7.jpg

Endexx Products to Restock in Mass Retail and Pharmacy Stores Across the United States


Released On: 6/29/2020
Views: 8634

https://s3.amazonaws.com/findit-pictures/6469/2aa7b5e2-d842-4fcb-9615-b7d3743b2fcc.jpg

Endexx Sponsors 5th Annual Sophie's Day Golf Tournament benefiting the Leukemia and Lymphoma Society


Released On: 6/26/2020
Views: 8230

https://s3.amazonaws.com/findit-pictures/6469/c4cf09e5-f405-4d25-a28f-616c3612ce94.jpg

Endexx Acquires RPA, Inc. to Expand the Phytobites and Equine Division


Released On: 5/22/2020
Views: 7943

https://s3.amazonaws.com/findit-pictures/6469/276c0118-c7de-4bb1-b7ca-a81d866ff27a.jpg

CBD Unlimited Applauds the Commencement of Clinical Trials on CBD’s Potential Role in Slowing COVID-19


Released On: 5/14/2020
Views: 8143

https://s3.amazonaws.com/findit-pictures/6469/bc0327eb-e859-4474-be7f-55599785db4c.jpg

CBD Unlimited Names Lawrence Hudson, MBA as Chief Marketing Officer


Released On: 5/12/2020
Views: 8592

https://s3.amazonaws.com/findit-pictures/6469/18ee81c6-6e61-4ba8-af83-ab8aa2bb1ccc.jpg

Bring Your Health On The Go With Mist-X and Drops X From CBD Unlimited


Released On: 5/2/2020
Views: 8300

https://s3.amazonaws.com/findit-pictures/6469/aa82d3bd-370d-4e0e-a5db-850e35b42799.jpg

Transition To A Healthier Lifestyle With Premium Hemp CBD Oil From CBD Unlimited


Released On: 4/27/2020
Views: 9035

https://s3.amazonaws.com/findit-pictures/6469/87615a3e-9068-4257-a7ce-f028b5fe87f2.jpg

CBD Unlimited Celebrates Earth Day Via Plantings Seeds Facebook Livestream Event


Released On: 4/22/2020
Views: 8615

https://s3.amazonaws.com/findit-pictures/6469/6e34121b-8350-401b-9f60-294cf0418434.jpg

CBD Unlimited Secures Additional Distribution Channels


Released On: 4/16/2020
Views: 8394

https://s3.amazonaws.com/findit-pictures/6469/f0bbed50-d4ad-43ec-b9ed-bb3c435f0344.jpg

CBD Unlimited Provides Quarterly Update and Reports Record Revenues


Released On: 4/6/2020
Views: 8154

https://s3.amazonaws.com/findit-pictures/6469/b8d14bd9-f4e7-4f02-af40-dca70d9385ae.jpg

Peter Governale Joins CBD Unlimited’s Board of Directors


Released On: 3/23/2020
Views: 8255

https://s3.amazonaws.com/findit-pictures/6469/6cb260d7-77aa-4486-b3e4-2dec26544eb7.jpg

CBD Unlimited Appoints Dr. Daniel S. Brandwein to its Board of Directors


Released On: 3/19/2020
Views: 8225

https://s3.amazonaws.com/findit-pictures/6469/fd224b95-4796-4f1d-9419-8dbd9a8794d9.jpg

CBD Unlimited Announces Acquisition of Kush, Inc.


Released On: 3/5/2020
Views: 8608

https://s3.amazonaws.com/findit-pictures/6469/3d54b657-7db2-4926-a05b-e45496f157c7.jpg

CBD Unlimited Exclusive Interview with Stock News Report at the Nasdaq MarketSite


Released On: 3/5/2020
Views: 8218

Load More wait

Map

CBD Unlimited

Get Directions

CBD Unlimited

  • 38246 North Hazelwood Circle
    Cave Creek, Arizona 85331
    United States
  • 480-999-0097