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AIkido Pharma Inc. - AIKI Stock Chart Technical Analysis for 01-26-2021

AIkido Pharma Inc. - AIKI Stock Chart Technical Analysis for 01-26-2021Subscribe to My MAIN Channel Here: Webinar - H...

Aikido Pharma Has Announced That It Secured Early Interest in Next Generation Radiotherapy

One of the key component of Convergent's PRRT prostate cancer therapy is its proprietary drug, CONV 01-α, a monoclonal antibody conjugated with 225Ac,  a radioactive alpha particle emitter. The function of CONV 01-α is unique in that it not only binds specifically to the PSMA receptor on prostate cancer cells, but also stimulates the internalization of the receptor along with itself and its powerful radioactive payload directly into tumor cells. Convergent is presently conducting two sets of human clinical trials using CONV 01-α as a single agent treatment for prostate cancer. The first is a Phase 1a/2a Single Ascending Dose Trial of CONV 01-α and the results are expected to be released in Q2 2021. In August of 2020, Convergent began a second Phase 1b/2a trial to test the efficacy of multiple ascending doses of CONV 01-α. If FDA approved, CONV 01-α would be the first antibody drug approved to direct a radioisotope into prostate cancer cells, and the first drug approved for the use of 225Ac in cancer treatment.


Using CONV 01-α, Convergent has developed a dual PRRT therapy by adding a second molecule also containing a radioactive isotope.  In this proprietary therapy, the second molecule has several key features:
--Like CONV 01-α, it binds specifically to the PSMA receptor on prostate cancer cells.  But it binds to a different epitope of PSMA, allowing both drugs to bind PSMA simultaneously and noncompetitively.  
--It has a different, non-overlapping biodistribution in the body than does CONV 01-α, reducing additive toxicity to healthy tissue when both drugs are administered.  
--When both CONV 01-α and the second molecule are bound to PSMA, CONV 01-α still causes the internalization of the PSMA, so the radioactive payloads of both CONV 01-α and the second molecule are delivered into the cancer cells.
These key features allow for a more powerful and effective treatment than using CONV 01-α alone, while minimizing double damage to healthy tissues. In fact, preliminary animal data indicate that the two molecules administered together act in a truly synergistic fashion, i.e., the effect of using both drugs together is significantly higher than the expected additive effects of using each separately.  
Convergent now has approval to begin human trials using CONV 01-α and PSMA I&T in a dual therapy, which are anticipated to begin in February of 2021. In these trials, Convergent will test PSMA I&T containing either 177Lu, a beta particle emitter, or 225Ac, the same alpha emitter in CONV 01-α. Convergent has approval to perform the three human trials listed below for this dual therapy, anticipated to begin in February of 2021:
  1. a Phase 1b/2a with the combination of CONV 01-α and PSMA I&T-β;
  2. a Phase 2b with the combination of PSMA I&T-β ± CONV 01-α, and
  3. a Phase 1b/2a with PSMA I&T-α ± CONV 01-α (i.e., both drugs with 225Ac, the α-particle emitter).

In a quote from Anthony Hayes, the CEO of Aikido Pharma, "This is by far the most advanced technology in which the Company has participated. The first of the human trials is wrapping up, with data to be reported shortly, and with the remaining trials either underway or scheduled to begin imminently. Participation in this advanced work represents a major and potentially transformative step for the Company and we are honored to be a part of it. I optimistically anticipate the first of the results to be released next quarter. We will update our shareholders as soon as the data is released.”


About AIkido Pharma Inc.
AIkido Pharma Inc. was initially formed in 1967 and is a biotechnology company with a diverse portfolio of small-molecule anti-cancer therapeutics. The Company's platform consists of patented technology from leading universities and researchers and we are currently in the process of developing an innovative therapeutic drug platform through strong partnerships with world renowned educational institutions, including The University of Texas at Austin and Wake Forest University. Our diverse pipeline of therapeutics includes therapies for pancreatic cancer, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). In addition, we are constantly seeking to grow our pipeline to treat unmet medical needs in oncology. The Company is also developing a broad-spectrum antiviral platform that may potentially inhibit replication of multiple viruses including Influenza, SARS-CoV (coronavirus), MERS-CoV, Ebolavirus and Marburg virus.


Forward-Looking Statements
Certain statements in this press release constitute "forward-looking statements" within the meaning of the federal securities laws. Words such as "may," "might," "will," "should," "believe," "expect," "anticipate," "estimate," "continue," "predict," "forecast," "project," "plan," "intend" or similar expressions, or statements regarding intent, belief, or current expectations, are forward-looking statements. While the Company believes these forward-looking statements are reasonable, undue reliance should not be placed on any such forward-looking statements, which are based on information available to us on the date of this release. These forward-looking statements are based upon current estimates and assumptions and are subject to various risks and uncertainties, including without limitation those set forth in the Company's filings with the SEC, not limited to Risk Factors relating to its business contained therein. Thus, actual results could be materially different. The Company expressly disclaims any obligation to update or alter statements whether as a result of new information, future events or otherwise, except as required by law.

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