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HPLC and UHPLC Chromatographic Column Research Report： the market size is projected to reach USD 2.53 billion by 2031
According to the new market research report “HPLC and UHPLC Chromatographic Column- Global Market Share and Ranking, Overall Sales and Demand Forecast 2025-2031”, published by QYResearch, the global HPLC and UHPLC Chromatographic Column market size is projected to reach USD 2.53 billion by 2031, at a CAGR of 5.4% during the forecast period.
Figure00001. Global HPLC and UHPLC Chromatographic Column Market Size (US$ million), 2020-2031
Source: QYResearch, "HPLC and UHPLC Chromatographic Column- Global Market Share and Ranking, Overall Sales and Demand Forecast 2025-2031”
As core tools of modern analytical chemistry, high performance liquid chromatography (HPLC) and ultra-high performance liquid chromatography (UHPLC) technologies play an irreplaceable role in pharmaceuticals, environmental monitoring, food safety, and life science research. In recent years, with the advancement of science and technology and changes in industry demand, the chromatographic column market is undergoing profound changes.
In terms of technology types, Reverse Phase Chromatography dominates the market, accounting for 56.45% of revenue in 2024. This method is widely preferred due to its versatility, high resolution, and compatibility with a broad range of compounds. It is followed by Normal Phase Chromatography (18.90%), Ion Exchange (8.42%), and other specialized techniques (16.23%) used for niche or highly specific applications.
The upgrading of quality control in the pharmaceutical industry and the expansion of emerging application areas have become the main driving forces, and technological innovations such as sub-2 micron fillers and core-shell columns continue to drive market growth. However, the market faces competitive pressure from alternative technologies such as capillary electrophoresis, limited supply of key raw materials, and challenges such as the short service life of UHPLC columns.
The future development of the market presents trends such as intelligent system integration of AI optimization functions, green design to reduce solvent consumption, and customized services to meet the needs of biopharmaceutical analysis. In the future, successful companies will be those industry leaders who can perfectly combine technological innovation with market demand and have a sustainable development vision.
Figure00002. Global HPLC and UHPLC Chromatographic Column Top 15 Players Ranking and Market Share (Ranking is based on the revenue of 2024, continually updated)
Source: QYResearch, "HPLC and UHPLC Chromatographic Column- Global Market Share and Ranking, Overall Sales and Demand Forecast 2025-2031”
According to QYResearch Top Players Research Center, the global key manufacturers of HPLC and UHPLC Chromatographic Column include Agilent Technologies, Waters, Shimadzu, Merck, Thermo Fisher, Hamilton, Danaher, Mitsubishi Chemical, PerkinElmer, Nacalai Tesque, etc. In 2024, the global top 10 players had a share approximately 73.0% in terms of revenue.
In terms of product type, currently Reverse Phase is the largest segment, hold a share of 56.45%.
In terms of product application, currently Pharmaceutical is the largest segment, hold a share of 45.47%.
About QYResearch
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QYResearch is a world-renowned large-scale consulting company. The industry covers various high-tech industry chain market segments, spanning the semiconductor industry chain (semiconductor equipment and parts, semiconductor materials, ICs, Foundry, packaging and testing, discrete devices, sensors, optoelectronic devices), photovoltaic industry chain (equipment, cells, modules, auxiliary material brackets, inverters, power station terminals), new energy automobile industry chain (batteries and materials, auto parts, batteries, motors, electronic control, automotive semiconductors, etc.), communication industry chain (communication system equipment, terminal equipment, electronic components, RF front-end, optical modules, 4G/5G/6G, broadband, IoT, digital economy, AI), advanced materials industry Chain (metal materials, polymer materials, ceramic materials, nano materials, etc.), machinery manufacturing industry chain (CNC machine tools, construction machinery, electrical machinery, 3C automation, industrial robots, lasers, industrial control, drones), food, beverages and pharmaceuticals, medical equipment, agriculture, etc.
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